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Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial Summary: SURPASS-4 was a Phase 3, open-label, randomized trial comparing tirzepatide (5 mg, 10 mg, or 15 mg once weekly) with insulin glargine once daily in patients with type 2 diabetes and increased cardiovascular risk whose glucose levels were inadequately controlled